A lot of confusions, controversies and phobias exist regarding the selection of potencies to be administered, after selecting the similimum. Everything is controversial in this area of applied homeopathy. Each homeopath has his own ways, and believes that only he is right.Young homeopaths get confused due to totally contradicting advice they get from their different teachers. Once similimum is selected for a case through a process of exhaustive case taking, repertorization and material medica study, the next issue that bothers a young homeopath the most is the selection of potency, dosage and repetitions. There are many ‘laws, principles, theories and guidelines’, given by different masters, most of them contradicting and conflicting with one another, which makes everything complex for a new comer. Through hard experience, most homeopaths finally settle into a stage where they make their own ‘private’ ‘laws’ regarding potency, dose and repetition, which they will never expose to the homeopathic community, for fear of being ridiculed as deviation from principles. Everybody wants to appear to be belonging to that respectable class of ‘classical homeopaths’, pretending to be strictly following all the ‘immutable’ ‘cardinal principles’ of ‘pure’ homeopathy. Please remember, all these ‘laws’ are made and practiced without even knowing what are the active principles of medicines we are using. Everything is pure speculation. Please remember, nobody actually knows what exactly happens during potentization. Nobody knows what are exactly the active principles of potentized drugs. Nobody exactly knows the molecular mechanism by which potentized drugs interacts with biological organism and creates a therapeutic effect. Nobody knows how low potencies are different from high potencies. Everything is based on speculations. Dynamism, vibrational theory, Vitalism- everything explained as phenomena happening ‘beyond science’. Through MIT, I am trying to resolve the issue of potencies in the light of scientifically viable working hypothesis regarding homeopathic therapeutics and potentization.